The main molecular mechanisms underlying methamphetamine-induced neurotoxicity and implications for pharmacological treatment
| Autor: | Liangpei Chen, Lvshuang Liao, Yong Wang, Yaxian Zhong, Kun Xiong, Chun-Xia Yi, Xue Yang, Yajun Du, Jie Yan, Jing He, Qiyan Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_treatment media_common.quotation_subject Excitotoxicity medicine.disease_cause neuroinflammation lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine neurotoxicity medicine oxidative stress methamphetamine Molecular Biology lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Neuroinflammation media_common Mechanism (biology) business.industry Neurotoxicity Meth Immunotherapy Methamphetamine medicine.disease 030104 developmental biology chemistry immunotherapy business Neuroscience excitotoxicity 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Frontiers in Molecular Neuroscience, Vol 11 (2018) |
| ISSN: | 1662-5099 |
| DOI: | 10.3389/fnmol.2018.00186 |
| Popis: | Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the accurate mechanism of toxic effect of the drug on central nervous system (CNS) has not yet been completely deciphered. Besides, effective treatment strategies toward METH neurotoxicity remain scarce and more efficacious drugs are to be developed. In this review, we summarize cellular and molecular bases that might contribute to METH-elicited neurotoxicity, which mainly include oxidative stress, excitotoxicity, and neuroinflammation. We also discuss some drugs that protect neural cells suffering from METH-induced neurotoxic consequences. We hope more in-depth investigations of exact details that how METH produces toxicity in CNS could be carried out in future and the development of new drugs as natural compounds and immunotherapies, including clinic trials, are expected. |
| Databáze: | OpenAIRE |
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