Preparation and Evaluation of N-Trimethyl Chitosan Nanoparticles of Flurbiprofen for Ocular Delivery
| Autor: | Kavita Singh, Prajakta N Joshi, Ujwala A Shinde, Divya D Jain |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug
Magnetic Resonance Spectroscopy Drug Compounding media_common.quotation_subject Flurbiprofen Nanoparticle Pharmacology Conjunctivitis Bacterial 03 medical and health sciences Cellular and Molecular Neuroscience Drug Delivery Systems 0302 clinical medicine Microscopy Electron Transmission N-trimethyl chitosan Spectroscopy Fourier Transform Infrared medicine Mucoadhesion Animals Particle Size media_common Trimethyl chitosan Chitosan Drug Carriers Chemistry Anti-Inflammatory Agents Non-Steroidal Sensory Systems 2-Hydroxypropyl-beta-cyclodextrin Bioavailability Ophthalmology 030221 ophthalmology & optometry Nanoparticles 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Current Eye Research. 44:575-582 |
| ISSN: | 1460-2202 0271-3683 |
| DOI: | 10.1080/02713683.2019.1567793 |
| Popis: | A major challenge in ocular therapeutics is poor bioavailability of drug, 1% or even less of the instilled dose is absorbed and frequent administration of conventional products leads to poor adherence to therapy. Hence, the present study is to synthesize N-trimethyl chitosan (TMC), a water-soluble chitosan derivative and to prepare flurbiprofen (FLU):hydroxyl propyl-β-cyclodextrin (HP-β-CD) complex-loaded nanoparticles for treatment of bacterial conjunctivitis which aims to increase the residence time in ocular tissue, thus enhancing patient compliance and improved efficacy.TMC was synthesized and characterized byN-methyl quaternization of CS was confirmed byThe developed TMC nanoparticles offered prolonged release potential for transmucosal ocular delivery of hydrophobic flurbiprofen. |
| Databáze: | OpenAIRE |
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