Effect of oenothera odorata root extract on microgravity and disuse-induced muscle atrophy
| Autor: | Ji Hyung Park, Kwang-Ho Lee, Tack Joong Kim, Han Sung Kim, J. Opitz, Dong Hyun Seo, Yong Hyeon Lee, Kazuya Kabayama |
|---|---|
| Přispěvatelé: | Publica |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Denervation
medicine.medical_specialty Pathology Article Subject biology Chemistry SOD1 Oenothera odorata lcsh:Other systems of medicine biology.organism_classification medicine.disease_cause lcsh:RZ201-999 Muscle atrophy Endocrinology Complementary and alternative medicine Internal medicine medicine Myocyte Viability assay medicine.symptom C2C12 Oxidative stress Research Article |
| Zdroj: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2015 (2015) |
| Popis: | Muscle atrophy, a reduction of muscle mass, strength, and volume, results from reduced muscle use and plays a key role in various muscular diseases. In the microgravity environment of space especially, muscle atrophy is induced by muscle inactivity. Exposure to microgravity induces muscle atrophy through several biological effects, including associations with reactive oxygen species (ROS). This study used 3D-clinostat to investigate muscle atrophy caused by oxidative stressin vitro, and sciatic denervation was used to investigate muscle atrophyin vivo. We assessed the effect ofOenothera odorataroot extract (EVP) on muscle atrophy. EVP helped recover cell viability in C2C12 myoblasts exposed to microgravity for 24 h and delayed muscle atrophy in sciatic denervated mice. However, the expressions of HSP70, SOD1, and ceramide in microgravity-exposed C2C12 myoblasts and in sciatic denervated mice were either decreased or completely inhibited. These results suggested that EVP can be expected to have a positive effect on muscle atrophy by disuse and microgravity. In addition, EVP helped characterize the antioxidant function in muscle atrophy. |
| Databáze: | OpenAIRE |
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