Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design

Autor:	Lijie Grace Zhang, Margaret Nowicki, Ali Khademhosseini, Wei Zhu, Haitao Cui, Xuan Zhou
Rok vydání:	2016
Předmět:	0301 basic medicine Engineering Biomedical Engineering Pharmaceutical Science Nanotechnology 02 engineering and technology Bone and Bones Article law.invention Biomaterials 03 medical and health sciences Tissue engineering law Human Umbilical Vein Endothelial Cells Humans 3D bioprinting Tissue Engineering business.industry Architectural design DUAL (cognitive architecture) 021001 nanoscience & nanotechnology Biocompatible material 030104 developmental biology Vascularized bone Printing Three-Dimensional Click chemistry 0210 nano-technology business Biomedical engineering
Zdroj:	Advanced Healthcare Materials. 5:2174-2181
ISSN:	2192-2640
Popis:	A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel-inspired chemistry and "thiol-ene" click reaction are used to regionally immobilize bioactive factors during construct fabrication for modulating or improving cellular events.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb5defdb5fbd25debe5c84cef25acdf https://doi.org/10.1002/adhm.201600505 Zobrazit plný text záznamu Plný text