Rostral Anterior Cingulate Glutamine/Glutamate Disbalance in Major Depressive Disorder Depends on Symptom Severity

Autor: Liliana Ramona Demenescu, Felicia von Düring, Oliver Speck, Meng Li, Mathias Vogel, Martin Walter, Joern Kaufmann, Joerg Frommer, Sarah Lison, Anton Lord, D Denzel, L Colic, Louise Martens
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Anhedonia
Cognitive Neuroscience
Glutamine
Glutamic Acid
Gyrus Cinguli
Severity of Illness Index
050105 experimental psychology
03 medical and health sciences
Glutamatergic
0302 clinical medicine
Internal medicine
metabolism [Gyrus Cinguli]
medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
ddc:610
metabolism [Depressive Disorder
Major]
metabolism [Glutamine]
Biological Psychiatry
Anterior cingulate cortex
Depression (differential diagnoses)
Depressive Disorder
Major
business.industry
05 social sciences
T-cell receptor
metabolism [Glutamic Acid]
Glutamate receptor
Middle Aged
medicine.disease
physiopathology [Depressive Disorder
Major]
Endocrinology
medicine.anatomical_structure
physiology [Anhedonia]
Major depressive disorder
Female
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Zdroj: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Biological psychiatry 4(12), 1049-1058 (2019). doi:10.1016/j.bpsc.2019.04.003
ISSN: 2451-9030
Popis: Background Patients with major depressive disorder (MDD) show glutamatergic deficits in the ventral anterior cingulate cortex. The glutamine/glutamate (Gln/Glu) ratio was proposed to be connected to glutamatergic cycling, which is hypothesized to be dysregulated in MDD. As an indicator of regional metabolite status, this ratio might be a robust state marker sensitive to clinical heterogeneity. Methods Thirty-two MDD patients (mean age 40.88 ± 13.66 years, 19 women) and control subjects (mean age 33.09 ± 8.24 years, 19 women) were compared for pregenual anterior cingulate cortex levels of Gln/Glu, Gln/total creatine (tCr), Glu/tCr, and gamma-aminobutyric acid/tCr as determined by high-field magnetic resonance spectroscopy. We tested if symptom severity (Hamilton Depression Rating Scale) and anhedonia (Snaith-Hamilton Pleasure Scale) influence the relation of metabolites to clinical symptoms. Results MDD patients showed higher Gln/Glu. This was driven by marginally higher Gln/tCr and nonsignificantly lower Glu/tCr. Groups defined by severity moderated relationship between Gln/Glu and the Hamilton Depression Rating Scale. Moreover, severe cases differed from both control subjects and moderate cases. Groups defined by the Snaith-Hamilton Pleasure Scale also displayed differential relationship between Gln/Glu and levels of anhedonia, predominantly driven by Gln/tCr. Conclusions We elaborate previous accounts of metabolite deficits in the anterior cingulate cortex toward increased Gln/Glu. There is a moderated relationship between severity and the ratio, which suggests consideration of different mechanisms or disease state for the respective subgroups in future studies.
Databáze: OpenAIRE
Externí odkaz: