Renal graft outcome in autosomal dominant medullary cystic kidney disease type 1
| Autor: | Soloukides, Andreas P., Moutzouris, Dimitrios Anestis D., Papagregoriou, Gregory N., Stavrou, Christoforos V., Constantinou-Deltas, Constantinos D., Tzanatos, Helen A. |
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| Přispěvatelé: | Constantinou-Deltas, Constantinos D. [0000-0001-5549-9169] |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male survival rate medicine.medical_specialty Autosomal dominant medullary cystic kidney disease Interstitial nephritis Urology Renal graft Disease Medullary cystic kidney disease autosomal dominant medullary cystic kidney disease type 1 Kidney transplantation autosomal dominant disorder End-stage renal disease medullary sponge kidney Nephronophthisis male medicine Humans controlled study human survival time outcome assessment clinical article Proportional hazards model business.industry adult article Graft survival Middle Aged medicine.disease Polycystic Kidney Autosomal Dominant Kidney Transplantation Transplantation Treatment Outcome surgical procedures operative female Nephrology kidney graft treatment outcome Kidney Failure Chronic Female business |
| Zdroj: | Journal of nephrology J.Nephrol. |
| Popis: | Background: Medullary cystic kidney disease (MCKD) is an inherited interstitial nephritis, leading to endstage renal disease (ESRD) between the fourth and seventh decade of life. MCKD shares clinical and morphological features with nephronophthisis, although advances in molecular genetics have distinguished these 2 entities. Data regarding graft survival after kidney transplantation in MCKD patients are extremely limited. The aim of this study was to compare renal graft survival in transplanted MCKD1 and non-MCKD1 patients, to discover whether renal transplantation can be considered as an acceptable treatment for MCKD. Methods: Thirty-three transplanted patients with MCKD1 and 33 controls (transplanted due to other causes) were included in the study. Graft losses were considered censored for death. Graft survival was evaluated with the Kaplan-Meier method, and comparisons between groups were made by log-rank test. Cox regression analysis was used to estimate the effect of several variables on graft survival, and the chi-square test was used to compare groups of categorical data. Results: The 1-year cumulative graft survival rate for the MCKD1 group was 97%, while at 5 and 10 years it was 94% and 86%, respectively. For the control group, the respective values at years 1, 5 and 10 were 97%, 97% and 90%. Comparisons of graft survival rates between the 2 groups revealed no significant differences. Conclusions: Renal graft survival of transplanted MCKD1 patients was not shown to be inferior in comparison with that for patients undergoing transplants due to other causes. Therefore, it may represent a treatment of choice in MCKD1 patients with ESRD. © 2013 Società Italiana di Nefrologia. 26 793 798 Cited By :3 |
| Databáze: | OpenAIRE |
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