Perinatal and childhood factors and risk of prostate cancer in adulthood: MCC-Spain case-control study
| Autor: | Juan Alguacil, Gemma Castaño-Vinyals, Manolis Kogevinas, Lourdes Mengual, José Juan Jiménez-Moleón, Javier Llorca, Virginia Lope, José Manuel Ruiz-Dominguez, Beatriz Pérez-Gómez, Trinidad Dierssen-Sotos, Marina Pollán, Angel Tabernero, Adonina Tardón, J.L. Ruiz-Cerdá, Esther García-Esquinas, Nuria Aragonés |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Epidemiology Perinatal factors Population Childhood factors 03 medical and health sciences Prostate cancer Early life factors 0302 clinical medicine Prostate Pregnancy Risk Factors medicine Humans 030212 general & internal medicine Family history Gleason score education Aged Gynecology Aged 80 and over education.field_of_study Obstetrics business.industry Puberty Case-control study Prostatic Neoplasms MCC-Spain Middle Aged Maternal age at birth medicine.disease medicine.anatomical_structure Oncology In utero Spain 030220 oncology & carcinogenesis Case-Control Studies Female business Body mass index |
| Zdroj: | CANCER EPIDEMIOLOGY r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 1877-7821 |
| Popis: | Background: In utero and early-life exposures are suspected to modulate the risk of prostate cancer. This study examines the influence of certain perinatal and childhood-related factors on prostate cancer risk overall and by Gleason score at biopsy. Methods: MCC-Spain is a multicase-control study where 1088 histologically-confirmed incident prostate cancer cases (aged 42-85 years) and 1345 population-based controls (aged 38-85 years), frequency matched by age and province of recruitment, were recruited in 7 Spanish provinces. Self-reported perinatal and childhood-related characteristics were directly surveyed by trained staff. The association with prostate cancer risk, globally and according to Gleason score at biopsy, was evaluated using logistic and multinomial regression mixed models, adjusting for age, family history of prostate cancer, educational level and body mass index one year before the interview, and including the province as a random effect term. Results: Most perinatal factors were not related to prostate cancer risk, with the exception of middle-high socioeconomic level at birth (OR for high grade tumors = 1.36; 95%CI = 1.09-1.68). Regarding puberty, risk rose by 6% for each year of delayed onset (OR = 1.06; 95%CI = 1.01-1.10; p trend = 0.016), with a clear excess of risk in men who reached puberty after age 15 (OR: 1.35; 95%CI = 1.08-1.68). A borderline significant positive association with prepubertal height was also observed (p trend = 0.094). Conclusion: Some exposures experienced in utero and during adolescence, when the prostate is still maturing, might be relevant for prostate cancer risk in adulthood. (C) 2016 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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