A randomised trial of oral gammaglobulin in low-birth-weight infants infected with rotavirus
| Autor: | Lex W. Doyle, A. M. L. Knoches, Graeme L. Barnes, P.H. Hewson, W.H. Kitchen, J.A. Mclellan |
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| Rok vydání: | 1982 |
| Předmět: |
Pediatrics
medicine.medical_specialty Birth weight Administration Oral Infant Premature Diseases medicine.disease_cause Placebo Excretion Random Allocation Double-Blind Method immune system diseases hemic and lymphatic diseases Rotavirus medicine Humans Enterocolitis Clinical Trials as Topic business.industry Infant Newborn virus diseases Gamma globulin General Medicine Infant Low Birth Weight Reoviridae Infections Low birth weight Diarrhea Infantile gamma-Globulins medicine.symptom business |
| Zdroj: | Lancet (London, England). 1(8286) |
| ISSN: | 0140-6736 |
| Popis: | Oral human gammaglobulin or placebo was given with each feed during the first week of life to 75 low-birth-weight babies. All were in a nursery where rotavirus was known to be endemic. 25 of the babies excreted rotavirus during the first 2 weeks of life. This group was regarded as the "challenge" group. Gammaglobulin administration was associated with delayed excretion of rotavirus and with milder symptoms of infection. Rotavirus-associated diarrhoea necessitating low-lactose feeds developed in 6 of 11 babies given placebo and 1 of 14 babies given gammaglobulin. Oral human gammaglobulin seems to protect low-birth-weight infants from diarrhoea caused by rotavirus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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