Cholecystokinin-producing (I) cells of intestinal mucosa in dexamethasone-treated rats
| Autor: | Gordana Cvijic, Radmila Glišić, Vesna Koko, Jasmina Obradovic, Maja Milošević |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Duodenum Physiology Clinical Biochemistry 030209 endocrinology & metabolism Endoplasmic Reticulum digestive system Biochemistry Dexamethasone Diabetes Mellitus Experimental Prediabetic State 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology Intestinal mucosa Internal medicine Diabetes mellitus medicine Animals Intestinal Mucosa Rats Wistar 030304 developmental biology Cholecystokinin 0303 health sciences Lamina propria business.industry digestive oral and skin physiology medicine.disease Rats medicine.anatomical_structure Diabetes Mellitus Type 2 Ultrastructure Immunohistochemistry business medicine.drug |
| Zdroj: | Regulatory Peptides. 171:6-10 |
| ISSN: | 0167-0115 |
| Popis: | The aim of this study was to investigate the morphological, immunohistochemical and ultrastructural changes of cholecystokinin-producing (I) cells of gastrointestinal mucosa in dexamethasone-treated rats (D). After 12-daily intraperitoneal administration of 2 mg/kg dexamethasone, rats developed diabetes similar to human diabetes mellitus type 2. The mean diameter of the duodenum was significantly decreased due to significant reduction of volume fraction and profile area of lamina propria. There was a decrease in volume fraction and number of cholecystokinin (CCK)-producing cells per mm 2 of mucosa, as well as their numerical density, but without statistical significance. Also, dexamethasone induced appearance of hyperactive duodenal I-cells with small number of granules and dilated endoplasmic reticulum. In conclusion, the present study showed that morphological changes in duodenum cholecystokinin-producing (I) cells occurred in diabetic rats, in a manner which, suggests compensatory effort of CCK cells in diabetic condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect