A blueprint for human whole-cell modeling
| Autor: | John A. P. Sekar, Jonathan R. Karr, Balázs Szigeti, Arthur P. Goldberg, Saahith Pochiraju, Yosef D. Roth |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Engineering Process management Computer science Systems biology MEDLINE Plan (drawing) Technology development General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences 0302 clinical medicine Blueprint Drug Discovery 030304 developmental biology 0303 health sciences business.industry Management science Applied Mathematics Cellular pathways Computer Science Applications 030104 developmental biology Modeling and Simulation business Whole cell 030217 neurology & neurosurgery |
| Popis: | Whole-cell models of human cells are a central goal of systems biology. Such models could help researchers understand cell biology and help physicians treat disease. Despite significant challenges, we believe that human whole-cell models are rapidly becoming feasible. To develop a plan for achieving human whole-cell models, we analyzed the existing models of individual cellular pathways, surveyed the biomodeling community, and reflected on our experience developing whole-cell models of bacteria. Based on these analyses, we propose a plan for a project, termed the Human Whole-Cell Modeling Project, to achieve human whole-cell models. The foundations of the plan include technology development, standards development, and interdisciplinary collaboration. |
| Databáze: | OpenAIRE |
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