Advances in understanding the biology and function of the G-CSF receptor
| Autor: | de Koning Jp, Touw Ip |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Neutropenia
Myeloid Acute myeloblastic leukemia Growth factor medicine.medical_treatment Hematology Biology medicine.disease Hematopoiesis Leukemia Myeloid Acute medicine.anatomical_structure Cytokine Cell surface receptor Receptors Granulocyte Colony-Stimulating Factor Immunology medicine Animals Humans Congenital Neutropenia Receptor Function (biology) |
| Zdroj: | Current Opinion in Hematology. 3:180-184 |
| ISSN: | 1065-6251 |
| Popis: | G-CSF is the major growth factor involved in the production of neutrophilic granulocytes. G-CSF exerts its function via the activation of a membrane receptor that belongs to the super-family of hematopoietin receptors, also referred to as class I cytokine receptors. In this review we summarize the current knowledge of the function of the G-CSF receptor in normal granulopoiesis, as well as in some patients with severe congenital neutropenia and acute myeloblastic leukemia, diseases characterized by disturbed myeloid maturation. |
| Databáze: | OpenAIRE |
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