Effective Targeted Chemoprophylaxis of Recurrent Liver Echinococcosis with Haplotype CYP1A2F1*A/A: a Clinical Case
| Autor: | V. S. Panteleev, M. A. Nartaylakov, M. I. Lukmanov, G. I. Lukmanova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
RD1-811 Genetic traits albendazole benzimidazole Albendazole Internal medicine medicine Cyst liver echinococcosis Genotyping RC254-282 parasitic liver diseases relapse Secondary prevention business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens General Medicine targeted therapy medicine.disease Echinococcosis genotyping Chemoprophylaxis Surgery Clinical case business medicine.drug |
| Zdroj: | Креативная хирургия и онкология, Vol 10, Iss 4, Pp 287-290 (2020) |
| ISSN: | 2076-3093 2307-0501 |
| DOI: | 10.24060/2076-3093-2020-10-4-287-290 |
| Popis: | Background . One of the main longterm quality criteria for treatment and prevention of echinococcosis is postoperative relapse, which rate varies widely within 3–54% between medical facilities. The genetic traits of recurrent liver echinococcosis comprise an important subject of research into its etiopathogenetic factors for an effective prognosis of cyst relapse and treatment personalisation. Materials and methods. Bashkir State Medical University (Ufa, Russia) provided facilities to study targeted chemoprophylaxis efficacy in a case of relapsed liver echinococcosis with haplotype CYP1A2F1*A/A ( AA ) and the UM phenotype of ultrarapid albendazole sulfoxidetoalbendazole sulfone metaboliser. Results and discussion. The clinical case presented illustrates the rationale behind personalised chemoprevention of recurrent echinococcosis with albendazole based on genotyping data. Genotyping allows detection of an ultrafast metaboliser haplotype in blood implicating a rapid degradation of administered albendazole, reduced antiparasitic impact of drug therapy and more feasible relapse, in contrast with a normal metaboliser phenotype. Conclusion . A successful secondary prevention of relapsed echinococcosis suggests the efficacy of personalising albendazolebased chemoprophylaxis of recurrent echinococcosis with genotyping data. |
| Databáze: | OpenAIRE |
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