MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not
| Autor: | Alexandra M. J. Langers, Daan W. Hommes, Lukas J. A. C. Hawinkels, Cornelis F. M. Sier, F.J.G.M. Kubben, J. J. van der Reijden, Hein W. Verspaget, W. van Duijn, Cornelis B.H.W. Lamers |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
Genotype Colorectal cancer Gelatinase A SNP Single-nucleotide polymorphism survival Polymorphism Single Nucleotide Medicine Humans Promoter Regions Genetic Molecular Diagnostics Metalloproteinase business.industry Cancer medicine.disease Prognosis Phenotype Oncology Matrix Metalloproteinase 9 Immunology Cancer research Matrix Metalloproteinase 2 metalloproteinase business Colorectal Neoplasms |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(-1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9(-1562CT) was not. Tumour MMP levels were not determined by their SNP genotypes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|