Effects of Curcumin on Tumour Necrosis Factor-alpha and Interleukin-6 in the Late Phase of Experimental Acute Pancreatitis
| Autor: | D. Haktanir-Yatkin, Kıvılcım Sönmez, Ahmet Gülçubuk, Seval Aydin, Kemal Altunatmaz, Hafize Uzun, Aydın Gürel |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Curcumin Necrosis medicine.medical_treatment Gastroenterology Pathology and Forensic Medicine Proinflammatory cytokine Random Allocation chemistry.chemical_compound Internal medicine medicine Animals Mesenteric lymph nodes Rats Wistar Pancreas Saline Analysis of Variance General Veterinary Interleukin-6 Pancreatitis Acute Necrotizing Tumor Necrosis Factor-alpha business.industry Interleukin medicine.disease Immunohistochemistry Rats Treatment Outcome medicine.anatomical_structure chemistry Acute Disease Immunology Acute pancreatitis Tumor necrosis factor alpha medicine.symptom business |
| Zdroj: | Journal of Veterinary Medicine Series A. 53:49-54 |
| ISSN: | 1439-0442 0931-184X |
| DOI: | 10.1111/j.1439-0442.2006.00786.x |
| Popis: | Summary Inflammatory cytokines have been demonstrated to play an important role in the induction and severity of acute pancreatitis (AP) in the recent studies. The aim of this study was to investigate the effects of curcumin on inflammatory cytokines, such as tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 in the late phase of AP. The study was conducted on 40 male Wistar Albino rats. The animals were divided randomly into four equal groups. AP was induced by the infusion of 3% sodium taurocholate into the biliopancreatic duct (in groups I and II). Starting on day 20 prior to the induction of AP, rats in group I received daily dose of 100 mg/kg of curcumin, dissolved in 9% ethanol via an intragastric tube. The same procedure was repeated for 6 days following the onset of AP. Group III was infused only on saline solution. Group IV (curcumin control group) received 9% ethanol via an intragastric tube, during the experimental period (totally 26 days). All the animals were sacrificed on day 6 after the collection of blood samples and serum TNF-alpha and IL-6 levels were determined. Tissue samples were taken from pancreas, mesenteric lymph nodes, liver, lungs, spleen and the kidneys for histopathological evaluation. Serum TNF-alpha and IL-6 levels in the group, which received curcumin (group I), were determined to be significantly lower than those of the untreated group (group II) (P |
| Databáze: | OpenAIRE |
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