Antimicrobial Resistance of Escherichia coli in Dairy Calves: A 15-Year Retrospective Analysis and Comparison of Treated and Untreated Animals
| Autor: | Matteo Tonni, Nicoletta Formenti, Federico Scali, Paolo Pasquali, Cristian Salogni, Laura Birbes, Mario D’Incau, Nicoletta Vitale, Giovanni Loris Alborali, Stefano Giovannini, Chiara Martinelli, Flavia Guarneri |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Florfenicol
environmental contamination Veterinary medicine macromolecular substances Biology 1-week-old calves Microbiology AMR surveillance chemistry.chemical_compound Antibiotic resistance Clavulanic acid SF600-1100 Enrofloxacin medicine ineffective treatments General Veterinary Sulfamethoxazole temporal dynamics virulence genes Amoxicillin Antimicrobial Trimethoprim chemistry QL1-991 Animal Science and Zoology Zoology medicine.drug |
| Zdroj: | Animals, Vol 11, Iss 2328, p 2328 (2021) Animals Volume 11 Issue 8 |
| ISSN: | 2076-2615 |
| Popis: | The health problem of antimicrobial resistance (AMR) involves several species. AMR surveillance is essential to identify its development and design control strategies however, available data are still limited in some contexts. The AMR profiles of 2612 E. coli strains isolated over a period of 15 years (2002–2016) from calf enteric cases were analyzed to determine the presence of resistance and their temporal dynamics. Furthermore, the AMR profiles and the presence of the major virulence genes of 505 E. coli strains isolated from 1-week- and 2-week-old calves, 406 treated with antimicrobials and 99 untreated, were analyzed and compared to investigate the potential effects of treatment on AMR and strain pathogenicity. Resistance to tetracycline (90.70%) was the most common, followed by resistance to sulfamethoxazole/trimethoprim (77.70%) and flumequine (72.10%). The significantly higher percentage of AMR and virulence gene expression recorded in treated calves, combined with the statistically higher resistance to sulfamethoxazole/trimethoprim in E. coli with K99, corroborates the notion of resistance being induced by the frequent use of antimicrobials, leading to treatments potentially becoming ineffective. The significantly higher resistance to amoxicillin/clavulanic acid, enrofloxacin, and florfenicol in isolates from 1-week-old calves suggests the role of the environment as a source of contamination that should be investigated further. |
| Databáze: | OpenAIRE |
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