Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia
| Autor: | Xiaoyan Tian, Rongrong Song, Dongfang Shen, Wenxu Sang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Models Molecular 0301 basic medicine Interleukin-1beta Immunology Hippocampus Morris water navigation task Resveratrol Hippocampal formation Antioxidants Melatonin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Malondialdehyde Stilbenes medicine Animals Memory impairment Rats Wistar Maze Learning Vascular dementia Neuroinflammation Memory Disorders Tumor Necrosis Factor-alpha Endocrine and Autonomic Systems Brain-Derived Neurotrophic Factor Dementia Vascular Recognition Psychology medicine.disease Glutathione Rats Disease Models Animal 030104 developmental biology Neurology chemistry Drug Therapy Combination Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuroimmunomodulation. 23:318-331 |
| ISSN: | 1423-0216 1021-7401 |
| DOI: | 10.1159/000454681 |
| Popis: | Objectives: This study was intended to investigate whether treatment with resveratrol and melatonin alone or in combination can exert neurorestorative effects in a rat model of vascular dementia. Methods: Briefly, male Wistar rats were subjected to permanent bilateral common carotid artery occlusion (BCCAO) by surgery. After 4 weeks, the cognitive deficits were assessed using the Morris water maze and novel object recognition tests. The biochemical parameters of oxidative stress and inflammation were also assessed. Results: Rats in the BCCAO group showed cognitive deficits, accompanied by oxidonitrosative stress, neuroinflammation, and a reduction in brain-derived neurotrophic factor (BDNF) in the hippocampus region. Moreover, the acetylcholinesterase activity in the hippocampus was found to be increased in the BCCAO group compared to the sham group. The 4-week treatment with melatonin (10 mg/kg) and resveratrol (20 mg/kg) alone and in combination (melatonin 5 mg/kg and reseveratrol 10 mg/kg) caused a significant improvement in the cognitive deficits induced by BCCAO, accompanied by a reversal of oxidonitrosative stress, neuroinflammation, and BDNF depletion in the hippocampus region. Additionally, the treatment with melatonin and resveratrol significantly decreased acetylcholinesterase activity compared to in the BCCAO group. Melatonin and resveratrol ameliorated the BDNF expression of hippocampal protein. Conclusion: These results emphasize that coadministration of melatonin and resveratrol can be beneficial in BCCAO-induced vascular dementia through changes in BDNF expressions. |
| Databáze: | OpenAIRE |
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