Ectonucleotidase Inhibitory and Redox Activity of Imidazole‐Based Organic Salts and Ionic Liquids
| Autor: | Mariana Neamtu, Jamshed Iqbal, Fliur Macaev, Jean Sévigny, Joanna Lecka, Veaceslav Boldescu, Sidra Hassan, Denis Prodius, Natalia Sucman |
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| Rok vydání: | 2018 |
| Předmět: |
Ionic Liquids
Salt (chemistry) Antineoplastic Agents Apoptosis 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Aldehyde Redox Antioxidants Carboplatin Structure-Activity Relationship chemistry.chemical_compound Cell Line Tumor Drug Discovery Animals Humans Imidazole Ectonucleotidase Enzyme Inhibitors General Pharmacology Toxicology and Pharmaceutics Cytotoxicity 5'-Nucleotidase Cell Proliferation Pharmacology chemistry.chemical_classification Mesocricetus Molecular Structure 010405 organic chemistry Singlet oxygen Organic Chemistry Imidazoles 0104 chemical sciences chemistry Benzaldehydes Ionic liquid Molecular Medicine |
| Zdroj: | ChemMedChem. 13:2297-2304 |
| ISSN: | 1860-7187 1860-7179 |
| DOI: | 10.1002/cmdc.201800520 |
| Popis: | Cytotoxicity against cancer and normal cells, inhibition of ectonucleotidase, and redox properties of a new group of imidazole-based organic salts and ionic liquids were studied. The tetrachloroferrate salt of a 1-methylimidazole derivative of salicylic aldehyde had most prominent inhibitory activity against ectonucleotidase as well as a higher cytotoxicity against HeLa cells and lower cytotoxicity against BHK-21 cells than the reference compound carboplatin. The studied compounds exhibited a moderate level of antioxidant activity with better results for the salicylic aldehyde derivatives than for spiropyrans. Moreover, these compounds did not generate singlet oxygen. |
| Databáze: | OpenAIRE |
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