Effects of pre- and postmenopausal use of exogenous hormones on receptor content in normal human breast tissue: A randomized study
| Autor: | Cecilia Magnusson, Ingemar Persson, Gunilla Hallberg, Tord Naessen |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Estrogen receptor Endogeny Luteal Phase Contraceptives Oral Hormonal Young Adult Endocrinology Pregnancy Internal medicine Progesterone receptor medicine Humans Endocrine system Gonadal Steroid Hormones Mammary Glands Human education Receptor Aged education.field_of_study business.industry Estrogen Receptor alpha Obstetrics and Gynecology Middle Aged medicine.disease Postmenopause Menopause Parity Follicular Phase Premenopause Drug Therapy Combination Female Receptors Progesterone business Algorithms Hormone |
| Zdroj: | Gynecological Endocrinology. 24:475-480 |
| ISSN: | 1473-0766 0951-3590 |
| Popis: | To examine the effects of exposure to endogenous and exogenous hormones on estrogen receptor-alpha (ERalpha) and progesterone receptor (PR) levels in normal human breast tissue.In a randomized study of women scheduled for mammary reduction plasty (n = 81), ERalpha and PR content in breast parenchyma was analyzed in premenopausal (n = 49) and postmenopausal (n = 16) women. Premenopausal women were randomized to surgery in the follicular or luteal phase of the menstrual cycle or after oral contraceptive treatment for 2 months. Postmenopausal women were randomized to sequential or estrogen-only therapy for 2 months prior to surgery.ERalpha content was higher in parous than in nulliparous (p = 0.009) premenopausal women and displayed a positive association with age (r(s) = 0.51, p = 0.0002). Compared with premenopausal women in the follicular phase, postmenopausal women had higher ERalpha content (p = 0.040) whereas premenopausal women on oral contraception had lower ERalpha (p = 0.048) and PR (p = 0.007) content. Smokers had lower PR content than non-smokers (p = 0.02).In the present study ERalpha content was higher in parous than in non-parous women and associated with premenopausal age. Short-term oral contraceptives yielded lower ERalpha and PR contents. Postmenopausal estrogen/progestogen combined therapy yielded lower PR content than estrogen-only therapy. |
| Databáze: | OpenAIRE |
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