Cytotoxic Prenylated Xanthones from the Young Fruit of Garcinia mangostana
| Autor: | Piniti Ratananukul, Sunit Suksamrarn, Nattapat Lartpornmatulee, Apichart Suksamrarn, Nitirat Chimnoi, Orapin Komutiban |
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| Rok vydání: | 2006 |
| Předmět: |
Magnetic Resonance Spectroscopy
food.ingredient Spectrophotometry Infrared Stereochemistry Metabolite Spectrometry Mass Fast Atom Bombardment chemistry.chemical_compound food Prenylation Cell Line Tumor Drug Discovery Carbohydrate Conformation Humans Cytotoxic T cell Cytotoxicity IC50 biology Traditional medicine Chemistry Clusiaceae General Chemistry General Medicine biology.organism_classification Antineoplastic Agents Phytogenic Epidermoid carcinoma Cell culture Fruit Xanthines Garcinia mangostana Spectrophotometry Ultraviolet Drug Screening Assays Antitumor Garcinia Human cancer |
| Zdroj: | ChemInform. 37 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200634209 |
| Popis: | Three new prenylated xanthones, mangostenones C (1), D (2), and E (3), together with 16 known xanthones 4-19, were isolated from the young fruit (7-week maturity stage) of Garcinia mangostana. The structural elucidation of the new compounds was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Compound 1 showed cytotoxic properties against three human cancer cell lines, epidermoid carcinoma of the mouth (KB), breast cancer (BC-1), and small cell lung cancer (NCI-H187), with IC50 values of 2.8, 3.53, and 3.72 microg/ml, respectively. Among the isolates, alpha-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells with an IC50 value of 0.92 microg/ml, an activity greater than that of the standard drug ellipticine (IC50 = 1.46 microg/ml). Compound 12 also showed the highest activity against KB cells, while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values of 2.08 microg/ml and 1.08 microg/ml. |
| Databáze: | OpenAIRE |
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