Intermolecular Antiselective and Enantioselective Reductive Coupling of Enones and Aromatic Aldehydes with Chiral Rh(Phebox) Catalysts

Autor:	Takahiro Adachi, Jun-ichi Ito, Takushi Shiomi, Hisao Nishiyama
Rok vydání:	2009
Předmět:	Coupling (electronics) Hydride Chemistry Organic Chemistry Intermolecular force Enantioselective synthesis Organic chemistry Physical and Theoretical Chemistry Biochemistry Medicinal chemistry Coupling reaction Catalysis
Zdroj:	Organic Letters. 11:1011-1014
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol802939u
Popis:	The intermolecular reductive coupling reaction of cyclopent-2-enone and aromatic aldehydes was realized by chiral rhodium-(bisoxazolinyl)phenyl catalysts, Rh(Phebox-Ph)(OAc)(2)(H(2)O), with diphenymethylsilane as a hydride donor to give the corresponding beta-hydroxyketones in high anti-selectivity (up to 96%) with high enantioselectivity (up to 93%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea37cc41656b340f3c52924bd4e1644 https://doi.org/10.1021/ol802939u Zobrazit plný text záznamu