Analysis of lifestyle factors in patients with concomitant chronic pancreatitis and liver cirrhosis

Autor: Peter Simon, P. Salacone, Kerstin Schütte, Irma Kuliaviene, Güralp O. Ceyhan, Matthias Kahl, Jon Andri Lutz, Truls Hauge, Generoso Uomo, Alexander Schneider, Ali A. Aghdassi, Birgit Schauer, Eija Tukiainen
Přispěvatelé: IV kirurgian klinikka, Clinicum, Department of Surgery, HUS Abdominal Center
Rok vydání: 2017
Předmět:
ALCOHOLIC CHRONIC-PANCREATITIS
Liver Cirrhosis
Male
Cirrhosis
Endocrinology
Diabetes and Metabolism
Disease
Gallstones
SUSCEPTIBILITY
Lifestyle factors
Gastroenterology
DISEASE
Body Mass Index
Co-incidence
Liver disease
0302 clinical medicine
Risk Factors
GENETIC POLYMORPHISMS
Smoking
ASSOCIATION
ETIOLOGY
3. Good health
Europe
ALDEHYDE DEHYDROGENASE
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
DRINKING HABITS
Chronic pancreatitis
Adult
medicine.medical_specialty
Alcohol Drinking
03 medical and health sciences
Internal medicine
Pancreatitis
Chronic
medicine
Humans
Pancreatitis
chronic
Life Style
Retrospective Studies
Pancreatic pain
Hepatology
business.industry
NATURAL-HISTORY
3126 Surgery
anesthesiology
intensive care
radiology
medicine.disease
3121 General medicine
internal medicine and other clinical medicine
Concomitant
Case-Control Studies
Multivariate Analysis
RISK-FACTORS
Etiology
Pancreatitis
business
Zdroj: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 17(5)
ISSN: 1424-3911
Popis: Background & objectives: Chronic pancreatitis (CP) and liver cirrhosis (LC) are common gastroentero-logical disorders but their co-incidence is considered to be rare. This study was designed to identify lifestyle factors that are associated with the development of concomitant LC in patients with CP. Methods: In a retrospective case-control study between 2000 and 2005 122 patients with both CP and LC and 223 matched control patients with CP and no known liver disease were identified in 11 European university medical centers. Another 24 patients and 48 CP controls were identified in the period between 2006 and 2012. Results: Alcoholism was most commonly regarded as aetiology for both CP (82.2%; 95% confidence interval (CI): 75.0-88.0%) and LC (79.5%; 95% CI: 72.0-85.7%) as compared to controls with CP only (68.6%; 95% CI: 62.7-74.1%). The preferred type of alcoholic beverage and pattern of alcohol intake were the only significant lifestyle factors in multivariate analysis. Frequency of alcohol intake (p = 0.105) and smoking status (p = 0.099) were not significant in bivariate analysis and dropped out of the multivariate model. Recurrent and chronic pancreatic pain was observed more often in patients with only CP, whereas gallstones were more common in individuals with both chronic disorders. Conclusions: These findings indicate that certain lifestyle factors might be important for the development of concomitant CP and LC. More studies will be needed to identify additional genetic and environmental factors underlying this association. (C) 2017 IAP and EPC. Published by Elsevier B.V. All rights reserved.
Databáze: OpenAIRE
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