Cyrene™ as an Alternative Sustainable Solvent for the Preparation of Poly(lactic-co-glycolic acid) Nanoparticles
| Autor: | Oliver Werz, Christian Grune, Dagmar Fischer, Jana Thamm |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Biocompatibility
Pharmaceutical Science Nanoparticle 02 engineering and technology 030226 pharmacology & pharmacy Preparation method Glycols 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Polylactic Acid-Polyglycolic Acid Copolymer Animals Lactic Acid Particle Size Glycolic acid Drug Carriers Chemistry technology industry and agriculture 021001 nanoscience & nanotechnology Biodegradable polymer Solvent PLGA Chemical engineering Solvents Nanoparticles Nanomedicine Female 0210 nano-technology Chickens Polyglycolic Acid |
| Zdroj: | Journal of Pharmaceutical Sciences. 110:959-964 |
| ISSN: | 0022-3549 |
| Popis: | Toxic and environmental harmful organic solvents are widely applied to prepare poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NP) in standard preparation methods. Alternative non-toxic solvents suffer from disadvantages like high viscosity and plasticizing effects. To overcome these hurdles, Cyrene™ as a new sustainable, non-toxic and low viscous solvent was used to formulate PLGA NPs. A new preparation method was developed and optimized. Small sized blank NPs around 220 nm with a narrow size distribution and highly negative charge (-23 mV) were obtained. To test the application for drug delivery, the lipophilic model drug atorvastatin was encapsulated in high drug loads with comparable physicochemical characteristics as the blank NPs, and a total drug release within 24 h. No changes of the crystallinity or plasticizing effects could be observed. Highly purified NPs were obtained with a residual Cyrene™ content2.5%. Finally, the biocompatibility of Cyrene™ itself and of the NPs formed in the presence of Cyrene™ was demonstrated in a hen's egg test. Conclusively, the use of Cyrene™ as solvent offers a simple, fast and non-toxic procedure for preparation of PLGA NPs as drug delivery systems circumventing the downsides of standard methods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|