Neuroprotective effect of magnesium on lipid peroxidation and axonal function after experimental spinal cord injury

Autor: Tuncer Süzer, H Islekel, Kadir Tahta, Erdal Coskun
Rok vydání: 1999
Předmět:
Male
aneurysm clip
lipid peroxide
magnesium
Turkey (republic)
Lipid peroxidation
chemistry.chemical_compound
Random Allocation
magnesium sulfate
rat
Spinal cord injury
Lipid peroxide
Magnesium
malonaldehyde
article
General Medicine
Evoked potentials
Malondialdehyde
Neuroprotective Agents
priority journal
Neurology
Anesthesia
sodium chloride
neuroprotection
Cord
N-Methylaspartate
Injections
Subcutaneous
animal experiment
chemistry.chemical_element
subcutaneous drug administration
Neuroprotection
Statistics
Nonparametric
animal tissue
Central nervous system disease
Magnesium Sulfate
male
statistical analysis
Evoked Potentials
Somatosensory
medicine
Animals
controlled study
nerve fiber
Spinal Cord Injuries
Analysis of Variance
nonhuman
Dose-Response Relationship
Drug
business.industry
evoked somatosensory response
medicine.disease
Rats
chemistry
Neurology (clinical)
Evoked Potentials
Somatosensory/*drug effects
Lipid Peroxidation/*drug effects
Magnesium Sulfate/administration & dosage/*therapeutic use
N-Methylaspartate/metabolism
Neuroprotective Agents/administration & dosage/*therapeutic use
Spinal Cord Injuries/*drug therapy/metabolism/physiopathology
Lipid Peroxidation
business
Zdroj: Spinal cord. 37(7)
ISSN: 1362-4393
Popis: Study design: An experimental study examining the neuroprotective effect of magnesium on axonal function and lipid peroxidation in a rat model of acute traumatic spinal cord injury. Objective: To determine the effectiveness of postinjury treatment with magnesium on evoked potentials and lipid peroxidation after spinal cord injury (SCI). Setting: Pamukkale University, Denizli, Turkey. Methods: Spinal cord injury occurred in 30 rats with an aneurysm clip at T9 and the rats were randomly assigned to undergo subcutaneous administration of one of the following at 1 h after injury: (1) Physiological saline (n = 10); (2) MgSO4, 300 mg/kg (n = 10) and (3) MgSO4, 600 mg/kg (n = 10). Spinal somatosensory evoked potentials (SSEPs) were recorded before injury, 30 min after injury and 3 h after injections. Rats were killed 24 h after the injury, and malondialdehyde (MDA) levels were measured. Results: Following SCI, there were significant decreases in the amplitudes of P1 and N1 (P 0.001) and only high-dose magnesium improved the SSEPs (P < 0.01). On the other hand, there was significant difference in lipid peroxide content between high-dose magnesium treated group and both of saline treated and low-dose magnesium treated groups (P < 0.01). Conclusion: These results suggest that magnesium has a dose-dependent neuroprotective effect on SSEPs and lipid peroxidation after experimental spinal cord injury.
Databáze: OpenAIRE
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