Myocardial preservation using celsior solution in cardiac transplantation: early results and 5-year follow-up of a multicenter prospective study of 70 cardiac transplantations
| Autor: | Jean Christian Roussel, Philippe Despins, Michèle Treilhaud, J.P. Remadi, J. L. Michaud, Oussana Al Habash, Daniel Duveau, Olivier Baron |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.medical_treatment Organ Preservation Solutions Cardiomyopathy Heart preservation Disaccharides law.invention Electrolytes Postoperative Complications Glutamates Randomized controlled trial law medicine Humans Histidine Mannitol Hospital Mortality Prospective Studies Prospective cohort study Survival rate Aged Heart transplantation business.industry Myocardium Organ Preservation Middle Aged medicine.disease Glutathione Surgery Survival Rate Transplantation Heart Transplantation Female Cardiology and Cardiovascular Medicine business Perfusion Follow-Up Studies |
| Zdroj: | The Annals of Thoracic Surgery. 73:1495-1499 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/s0003-4975(02)03424-0 |
| Popis: | Several storage methods using a wide variety of extracellular or intracellular solutions applied either as continuous perfusion, intermittent perfusion, or simple immersion of the heart have been commonly used. We have performed a prospective randomized multicenter study of 70 cardiac transplantation recipients to evaluate the Celsior solution for cardiac preservation.Seventy consecutive patients were included in this trial and received a cardiac graft arrested and preserved with Celsior. The first follow-up period was 1 month. The mean age of the recipients was 49 years (range, 28 to 66 years), and 81.7% were male. The main disease was nonobstructive cardiomyopathy (64.3%). The age range of donors was between 14 and 56 years with a mean of 33 years. The majority of grafts (73%) were stored in 1 L of Celsior. A midterm follow-up at 5 years was performed and was 100% complete.The operative mortality (30-day) rate was 6 of 70 (8.6%). Sixty-three patients (90%) had at least satisfactory hemodynamic measurements on day 2. The first postoperative echocardiograms showed good myocardial performance for 90% of the grafts. Actuarial survival rate at 5 years was 75% +/- 5.1%.The use of Celsior in cardiac transplantation was safe and very effective. This solution proved very valuable in at-risk patients. |
| Databáze: | OpenAIRE |
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