Overall survival of elderly patients with breast cancer is not related to breast-cancer specific survival: A single institution experience in Japan

Autor:	Fumiaki Yotsumoto, Haruko Takuwa, Wakako Tsuji
Rok vydání:	2018
Předmět:	Male Oncology Cancer Research Population ageing medicine.medical_specialty Breast Neoplasms Disease-Free Survival Breast Neoplasms Male Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Drug Therapy Japan Internal medicine medicine Overall survival Humans 030212 general & internal medicine Single institution Aged Retrospective Studies Aged 80 and over business.industry Standard treatment Age Factors Cancer Retrospective cohort study General Medicine Prognosis medicine.disease Survival Rate 030220 oncology & carcinogenesis Female Neoplasm Recurrence Local business
Zdroj:	Breast Disease. 37:177-183
ISSN:	1558-1551 0888-6008
DOI:	10.3233/bd-170280
Popis:	BACKGROUND As the aging population grows, the number of elderly breast cancer patients has rapidly increased especially in Japan; a suitable treatment for elderly patients, considering chronic comorbidities and treatment tolerance, is urgently needed. METHODS In this retrospective study, 286 elderly breast cancer patients were investigated. Tumor characteristics and survival outcome were compared between 70-79-year-old and ≥ 80-year-old groups. Disease-free survival, overall survival, and breast cancer-specific survival were compared, and the effect of variables was analyzed statistically. For resectable cases, prognoses were compared based on treatment (standard therapy or undertreated). RESULTS Tumor characteristics were similar between groups, but the Ki-67 labeling index tended to be higher in older patients. Elderly patients with resectable cancer tended to be undertreated. During the median 59-month follow-up period, overall survival was significantly worse in the ≥80-year-old than in the 70-79-year-old group (p < 0.001), but disease-free and breast cancer-specific survivals were equivalent. Recurrence or death event hazard rates tended to be lower in patients receiving standard treatment. CONCLUSIONS Standard multidisciplinary treatment for breast cancer prevents recurrence and metastasis and tends to extend breast cancer-specific survival even in elderly patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de940c7cf6c3e0bca2302d43035a8f4a https://doi.org/10.3233/bd-170280 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.