The alcohol dehydrogenases ofSaccharomyces cerevisiae: a comprehensive review
| Autor: | Jacobus Albertyn, James C. du Preez, Olga de Smidt |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Saccharomyces cerevisiae Proteins
biology Saccharomyces cerevisiae Alcohol Dehydrogenase Oxidation reduction Alcohol General Medicine Research opportunities biology.organism_classification Applied Microbiology and Biotechnology Microbiology Kinetics Scientific analysis chemistry.chemical_compound chemistry Biochemistry Alcohols Gene Expression Regulation Fungal biology.protein NAD+ kinase Oxidation-Reduction Yeast genome Alcohol dehydrogenase |
| Zdroj: | FEMS Yeast Research. 8:967-978 |
| ISSN: | 1567-1364 1567-1356 |
| DOI: | 10.1111/j.1567-1364.2008.00387.x |
| Popis: | Alcohol dehydrogenases (ADHs) constitute a large family of enzymes responsible for the reversible oxidation of alcohols to aldehydes with the concomitant reduction of NAD(+) or NADP(+). These enzymes have been identified not only in yeasts, but also in several other eukaryotes and even prokaryotes. The ADHs of Saccharomyces cerevisiae have been studied intensively for over half a century. With the ever-evolving techniques available for scientific analysis and since the completion of the Yeast Genome Project, a vast amount of new information has been generated during the past 10 years. This review attempts to provide a brief summary of the wealth of knowledge gained from earlier studies as well as more recent work. Relevant aspects regarding the primary and secondary structure, kinetic characteristics, function and molecular regulation of the ADHs in S. cerevisiae are discussed in detail. A brief outlook also contemplates possible future research opportunities. |
| Databáze: | OpenAIRE |
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