Crossover Analysis of the Astringent, Antimicrobial, and Anti-inflammatory Effects of Illicium verum/Star Anise in the Oral Cavity

Autor:	Ali A Assiry, Shaeesta Khaleelahmed Bhavikatti, Mohmed Isaqali Karobari, Anand Marya
Rok vydání:	2021
Předmět:	Adult Male food.ingredient Article Subject Adolescent Astringent medicine.drug_class Anti-Inflammatory Agents Mouthwashes Placebo Illicium General Biochemistry Genetics and Molecular Biology Anti-inflammatory Group B law.invention Young Adult 03 medical and health sciences 0302 clinical medicine food Anti-Infective Agents Double-Blind Method Randomized controlled trial law medicine Humans Astringents Mouth Cross-Over Studies General Immunology and Microbiology Traditional medicine Plant Extracts business.industry Age Factors Mouth Mucosa 030206 dentistry General Medicine Antimicrobial Crossover study Medicine Ayurvedic Treatment Outcome Research Design 030220 oncology & carcinogenesis Medicine Female Periodontal Index business Illicium verum Research Article
Zdroj:	BioMed Research International, Vol 2021 (2021) BioMed Research International
ISSN:	2314-6141 2314-6133
DOI:	10.1155/2021/5510174
Popis:	Introduction. Illicium verum commonly known as star anise has been widely used in many Asian countries for pharmaceutical treatment for many diseases. The aim of the present study was to investigate the anti-inflammatory, astringent, and antimicrobial properties of an Illicium verum mouthwash. Methods. The present double blinded randomized clinical trial was conducted on fifty subjects, divided into groups A and B. Illicium verum mouthwash (group A) and placebo (group B) were provided to subjects for 21 days; after 14 days, washout period mouthwashes were switched as per crossover design between groups for 21 days. The gingival index (GI), papillary bleeding index (PBI), and oral microbial count were recorded at each stage of study. Results. The significant intragroup difference was observed, before crossover in group A and after crossover in group B for GI, PBI, and oral microbial count at different stages of study. On comparing both group A and group B at the first and second follow-up for GI, PBI, and oral microbial count, a statistically significant difference ( p < 0.05 ) was observed. A statistically highly significant mean intergroup and intragroup difference was seen for all the clinical parameters at different stages of study. Conclusion. The study revealed that the Illicium verum/star anise has potent antibacterial, anti-inflammatory, and astringent properties.
Databáze:	OpenAIRE
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