Sweet Relief: Determining the Antimicrobial Activity of Medical Grade Honey Against Vaginal Isolates of Candida albicans
| Autor: | John P Leeming, Renée Hermanns, Esther T van der Werf, Niels A J Cremers |
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| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
antibiotic resistance Antibiotic resistance Plant Science candida 03 medical and health sciences Minimum inhibitory concentration 0302 clinical medicine medicine 030212 general & internal medicine Vaginitis Candida albicans lcsh:QH301-705.5 Ecology Evolution Behavior and Systematics Candida 0303 health sciences biology Traditional medicine 030306 microbiology business.industry recurrent vulvovaginal candidiasis Candidiasis food and beverages biology.organism_classification Antimicrobial medicine.disease candidiasis Corpus albicans Medical grade honey Fungicide Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] vaginitis lcsh:Biology (General) Recurrent vulvovaginal candidiasis medical grade honey business |
| Zdroj: | Journal of Fungi, 5, 3 Hermanns, R, Cremers, N A J, Leeming, J P & van der Werf, E T 2019, ' Sweet Relief : Determining the Antimicrobial Activity of Medical Grade Honey Against Vaginal Isolates of Candida albicans ', Journal of Fungi, vol. 5, no. 3, 85 . https://doi.org/10.3390/jof5030085 Journal of Fungi, Vol 5, Iss 3, p 85 (2019) Journal of Fungi, 5 |
| ISSN: | 2309-608X |
| Popis: | Contains fulltext : 215323.pdf (Publisher’s version ) (Open Access) Recurrent vulvovaginal candidiasis (RVVC) is predicted to increase to almost 158 million cases annually by 2030. Extensive self-diagnosis and easily accessible over-the-counter (OTC) fungistatic drugs contribute to antifungal-resistance, illustrating the need for novel therapies. Honey possesses multiple antimicrobial mechanisms, and there is no antimicrobial resistance towards honey reported. We evaluated the susceptibility of five clinical isolates of Candida albicans and a control strain to regular honey and a medical grade honey (MGH) gel formulation (L-Mesitran, containing 40% honey and vitamins C and E) using an adapted version of the EUCAST protocol at pH 5.2, 4.6, and 4.0. 40% regular honey did not kill or inhibit C. albicans. In contrast, the minimal inhibitory concentration (MIC) of L-Mesitran was 25%-50%, while fungicidal effects occurred at a 50% concentration (MBC) of the MGH formulation, except for one strain which was not killed at pH 4.0. Overall, pH had little effect on antimicrobial activity. MGH formulation L-Mesitran has antimicrobial activity against C. albicans over a relevant pH range. The vitamin supplements or other components of L-Mesitran may enhance the antifungal activity of the honey. This study supports performing clinical trials for conditions, such as RVVC, to find an alternative to available OTC fungistatic drugs. |
| Databáze: | OpenAIRE |
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