The Value of 99mTc ECD SPECT With Statistical Image Analysis on Enhancing the Early Diagnosis of Primary Progressive Aphasia
| Autor: | Cheng-Yu Wei, Pai-Yi Chiu, Guang-Uei Hung, Hiroshi Matsuda, Po-Nien Hou |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
030218 nuclear medicine & medical imaging Primary progressive aphasia 03 medical and health sciences 0302 clinical medicine Aphasia medicine Humans Radiology Nuclear Medicine and imaging Statistical analysis Cysteine Cerebral perfusion pressure Aged Tomography Emission-Computed Single-Photon business.industry Neuropsychology Organotechnetium Compounds General Medicine Middle Aged medicine.disease Aphasia Primary Progressive Early Diagnosis Data Interpretation Statistical 99mtc ecd Female Radiology Radiopharmaceuticals Differential diagnosis Alzheimer's disease medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Clinical Nuclear Medicine. 42:e117-e120 |
| ISSN: | 0363-9762 |
| DOI: | 10.1097/rlu.0000000000001475 |
| Popis: | A 64-year-old woman with poor short-term memory was first suspected as early Alzheimer disease. Tc ECD brain SPECT was arranged for differential diagnosis. A small area of mild hypoperfusion was noted in the left temporal lobe on conventional display. Further statistical analysis of SPECT with an easy Z-score imaging system showed large areas of distinct hypoperfusion in left precentral and perisylvian cortical areas, compatible with typical pictures of nonfluent variant primary progressive aphasia (PPA), but no involvement in areas characteristic for Alzheimer disease. Further detailed neuropsychological examination and 6 months of clinical follow-up confirmed the final diagnosis of PPA. |
| Databáze: | OpenAIRE |
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