Vitamin D deficiency in children with epilepsy taking valproate and levetiracetam as monotherapy
| Autor: | Teodoro Durá-Travé, Fidel Gallinas-Victoriano, María Malumbres-Chacón, Paula Moreno-González, María Eugenia Yoldi-Petri, Sergio Aguilera-Albesa |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Levetiracetam Adolescent Gastroenterology vitamin D deficiency 03 medical and health sciences Epilepsy 0302 clinical medicine 030225 pediatrics Internal medicine Prevalence Vitamin D and neurology Humans Medicine Child Blood testing business.industry Seizure types Valproic Acid Healthy subjects Vitamin D Deficiency medicine.disease Cross-Sectional Studies Neurology Etiology Female lipids (amino acids peptides and proteins) Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Epilepsy Research. 139:80-84 |
| ISSN: | 0920-1211 |
| DOI: | 10.1016/j.eplepsyres.2017.11.013 |
| Popis: | The aim of this study is to evaluate if valproate (VPA) and levetiracetam (LEV) as monotherapy are associated with vitamin D deficiency among children with epilepsy.A cross-sectional clinical (seizure types, aetiology of epilepsy, dosage, drug levels, and duration of AED treatment) and blood testing (calcium, phosphorus, 25-OHD and PTH) study was accomplished in 90 epileptic children (AED group: 59 receiving VPA, and 31 receiving LEV) and a control group (244 healthy subjects). 25-OHD levels were categorized as low (20ng/ml), borderline (20-29ng/ml), or normal (30ng/ml) RESULTS: The average dosage of VPA and LEV was 20.7±4.7mg/kg/d and 24.1±7.9mg/kg/d, respectively. The mean duration of VPA therapy was 2.5±1.4years, and with LEV was 2.3±1.6years. Mean calcium and 25-OHD levels were significantly higher (p0.05) in the control group. There was a negative correlation (p0.01) between 25-OHD and VPA levels (r=-0.442). Vitamin D deficiency (%) was significantly higher (p0.05) in VPA (24.1%) and LEV (35.5%) groups than in control group (14%). The multiple logistic regression analysis showed that VPA monotherapy (OR: 1.9, CI 95%: 1.1-3.8) and LEV monotherapy (OR: 3.3, CI 95%: 1.5-7.5) were associated with an increased risk of vitamin D deficiency.The prevalence of vitamin D deficiency is common in children with epilepsy taking VPA or LEV. Hence vitamin D status of children treated with VPA and LEV should be regularly monitored and vitamin D supplements should be considered on an individual basis. |
| Databáze: | OpenAIRE |
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