Borrelia burgdorferi specific serum and cerebrospinal fluid antibodies in Lyme neuroborreliosis
| Autor: | Annukka Pietikäinen, Otto Glader, Elisa Kortela, Mari Kanerva, Jarmo Oksi, Jukka Hytönen |
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| Přispěvatelé: | HUS Inflammation Center, Infektiosairauksien yksikkö |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
Adult Male History Polymers and Plastics Lyme neuroborreliosis General Medicine DIAGNOSIS Antibodies Bacterial Industrial and Manufacturing Engineering Anti-Bacterial Agents Infectious Diseases Cerebrospinal fluid Serology Borrelia burgdorferi Group 3121 General medicine internal medicine and other clinical medicine Borrelia burgdorferi Humans Female Business and International Management Lyme borreliosis |
| Popis: | Publisher Copyright: © 2022 The Author(s) We used definite Lyme neuroborreliosis (LNB) adult patient acute and convalescent phase serum (n = 63 and 61, respectively) and cerebrospinal fluid (CSF; acute n = 63, 3 weeks timepoint n = 41) samples to characterize Borrelia burgdorferi specific antibody responses in patient subgroups categorized by demographics, infection manifestation and phase, infecting B. burgdorferi genospecies, received antibiotic treatments, and treatment outcome. B. burgdorferi antibodies were analyzed using 4 different assays incorporating a large array of antigens. We observed that B. burgdorferi specific serum antibodies show a universal, antigen independent declining trend after antibiotic treatment of LNB at 1 year. Antibodies declined similarly among women and men over time, and the decline was independent of patient age. The antibody responses were independent of the predominant LNB manifestation, treatment received by the patient, infecting B. burgdorferi genospecies, or the subjective improvement experienced by the patients. Finally, the antibody specificities in CSF reflected the specificities observed in serum samples. |
| Databáze: | OpenAIRE |
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