Correlation of respiratory parameters in hamsters with the lung deposition of radiolabeled cigarette smoke
| Autor: | Michael R. Guerin, I.B. Rubin, P. Nettesheim, J. Kendrick, B.E. Gill |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Respiratory rate Physiology Diacetyl Biochemistry Cricetinae Respiration Tidal Volume medicine Animals Respiratory system Lung Tidal volume General Environmental Science Smoke Mesocricetus biology Chemistry Smoking respiratory system biology.organism_classification Disease Models Animal medicine.anatomical_structure Environmental chemistry Lung Volume Measurements Respiratory minute volume |
| Zdroj: | Environmental Research. 16:70-76 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/0013-9351(78)90143-3 |
| Popis: | An evaluation was made of the relationship between respiration and deposition of cigarette smoke particulate matter in the lungs of Syrian golden hamsters. The hamsters were exposed to radiolabeled cigarette smoke while their respiratory rates and tidal volumes were monitored and recorded. The amount of total particulate matter deposited in the lungs correlated linearly with the respiratory parameters. For all tests, the sample correlation coefficient for lung deposition with minute volume was 0.75, with tidal volume, 0.84, and with respiratory rate, 0.52. Respiration characteristics of hamsters that had been smoking for 6 months were measured during their course of 12 daily cigarettes. The average volume and rate measurements during the smoke periods were essentially the same as for the beginning hamsters. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|