CARD15/NOD2 mutations in Crohn's disease
| Autor: | Jean-Pierre Hugot |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Nod2 Signaling Adaptor Protein
Biology medicine.disease_cause Inflammatory bowel disease General Biochemistry Genetics and Molecular Biology History and Philosophy of Science Environmental risk Crohn Disease NOD2 medicine Humans Genetic Predisposition to Disease Card15 nod2 Gene Genetics Mutation Crohn's disease Innate immune system General Neuroscience Intracellular Signaling Peptides and Proteins Chromosome Mapping medicine.disease digestive system diseases Immunity Innate Immunology |
| Zdroj: | Annals of the New York Academy of Sciences. 1072 |
| ISSN: | 0077-8923 |
| Popis: | Inflammatory bowel diseases (IBDs) are complex genetic disorders characterized by a complex interplay between genetic and environmental risk factors. At least ten genes or anonymous loci have been proposed to play a role in IBD. Among them, the best studied is CARD15/NOD2, a gene coding for a protein involved in bacterial recognition by cells involved in innate immunity. Despite a large amount of work, a consensus model explaining the effect of Card 15/NoD2 mutations did not emerge, and the disease mechanisms are still subject to debate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text