Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

Autor:	R. T. Constable, K.P. Lesch, Lise Gutknecht, Eliza Congdon, Turhan Canli
Rok vydání:	2005
Předmět:	Adult Genetic Markers Male Serotonin medicine.medical_specialty Adolescent Genotype DNA Mutational Analysis Emotions Neuropsychological Tests Tryptophan Hydroxylase Amygdala Internal medicine medicine Humans Genetic Predisposition to Disease Genetic Testing Gene Biological Psychiatry TPH2 medicine.diagnostic_test Mood Disorders Tryptophan Genetic Variation Tryptophan hydroxylase Magnetic Resonance Imaging Functional imaging Psychiatry and Mental health Endocrinology medicine.anatomical_structure Neurology Mutation Female Neurology (clinical) Functional magnetic resonance imaging Psychology Neuroscience Photic Stimulation psychological phenomena and processes
Zdroj:	Journal of Neural Transmission. 112:1479-1485
ISSN:	1435-1463 0300-9564
Popis:	The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de84a25636c25b47e74e46c46d0b88f3 https://doi.org/10.1007/s00702-005-0391-4 Zobrazit plný text záznamu Full text from SpringerLink