Depressor action of l-threo-dihydroxyphenylserine in the rat nucleus tractus solitarii
| Autor: | Yoshimi Misu, Yoshio Goshima, Jin-Liang Yue, Takeaki Miyamae |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Blood Pressure Pharmacology Levodopa Norepinephrine chemistry.chemical_compound Heart Rate Internal medicine Bradycardia Solitary Nucleus medicine Animals Drug Interactions Rats Wistar Neurotransmitter chemistry.chemical_classification Aromatic L-amino acid decarboxylase Dose-Response Relationship Drug Solitary nucleus Stereoisomerism Dihydroxyphenylalanine Rats Amino acid Endocrinology Droxidopa chemistry Competitive antagonist Depression Chemical Catecholamine Hypotension circulatory and respiratory physiology medicine.drug |
| Zdroj: | European Journal of Pharmacology. 300:105-108 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(95)00875-6 |
| Popis: | Microinjections of l - threo -dihydroxyphenylserine ( l - threo -DOPS, 0.1–3 ng), a synthetic precursor amino acid of noradrenaline, into the medial area of the nucleus tractus solitarii produced dose-dependent depressor and bradycardic responses in anesthetized rats treated with or without i.p. 3-hydroxybenzylhydrazine, a central inhibitor of l -aromatic amino acid decarboxylase. d - threo -DOPS (3 ng) produced no effect. l -Dihydroxyphenylalanine ( l -DOPA) methyl ester (1 μg), a competitive antagonist of l -DOPA, microinjected into the nucleus tractus solitarii, blocked the depressor and bradycardic responses to l - threo -DOPS. l - threo -DOPS itself produces vasodepressor actions without its conversion to noradrenaline, probably via a recognition site for l -DOPA in the rat nucleus tractus solitarii. |
| Databáze: | OpenAIRE |
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