Multicentric Castleman’s disease in human immunodeficiency virus infection: two case reports

Autor:	Amanda Caroline Ribeiro Sales, Marta Iglis de Oliveira, Evônio de Barros Campelo Júnior, Claudia Fernanda Azevedo Braga Albuquerque, Paulo Sérgio Ramos de Araújo, Valter Romão de Souza Junior
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine Adult Male Pathology medicine.medical_specialty Biopsy Population Castleman’s disease lcsh:Medicine Case Report HIV Infections Disease Lymph nodes enlargement Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Surgical oncology medicine Humans education Lymph node HHV-8 education.field_of_study business.industry Castleman Disease lcsh:R HIV General Medicine Herpesviridae Infections medicine.disease 030112 virology medicine.anatomical_structure Cervical lymph nodes 030220 oncology & carcinogenesis Herpesvirus 8 Human Lymph Lymph Nodes Differential diagnosis business Immunocompetence
Zdroj:	Journal of Medical Case Reports, Vol 12, Iss 1, Pp 1-4 (2018) Journal of Medical Case Reports
ISSN:	1752-1947
DOI:	10.1186/s13256-018-1656-5
Popis:	Background Castleman’s Disease is a rare B-cell lymphoproliferative disease. It is mostly benign and is characterized by non-neoplastic lymph node hypertrophy, associated with infection by human herpesvirus-8 in people with the human immunodeficiency virus/acquired immunodeficiency syndrome. Although the unicentric or localized form presents as benign, the multifocal form can manifest severe systemic symptoms. We report two unusual cases of men presenting cervical enlarged lymph nodes that were believed to be infectious. Case presentation The first case is a 41-year-old feoderm man who presented to the Department of Infectious Diseases of the Hospital das Clínicas in May 2015, with irregular fever history (38–39 °C), dyspnea, weight loss (8 kg/1 year), and asthenia with increased cervical lymph nodes of 1-year duration. His immunohistochemical diagnosis presented Castleman’s disease in plasmacytic/diffuse form. In the second case, a 35-year-old feoderm man presented at the same hospital with multiple cervical enlarged lymph nodes and histopathological evidence of Castleman’s disease associated with human herpesvirus-8. Conclusion Considering the importance of differential diagnosis of lymphoid disorders, Castleman’s disease is a challenging diagnosis in people living with human immunodeficiency virus/acquired immunodeficiency syndrome and can be easily misdiagnosed when lymphoid disorders are present in the human immunodeficiency virus/acquired immunodeficiency syndrome population due to nonspecific symptoms and signs.
Databáze:	OpenAIRE
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