Behavior of silica particles introduced into an isolated rat heart as potential drug carriers
| Autor: | W. Mazurek, Bartosz Grotthus, H Gliniak, A Szelag, M Skrzypiec, B Krajewska, Dariusz Biały, Krzysztof Maruszewski, Beata Borak, Piotr Ziółkowski, J. Arkowski, Magdalena Wawrzyńska |
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| Rok vydání: | 2007 |
| Předmět: |
Materials science
Silicon dioxide Biomedical Engineering Lumen (anatomy) Nanoparticle Biocompatible Materials Bioengineering In Vitro Techniques Biomaterials chemistry.chemical_compound Coronary circulation Materials Testing medicine Animals Particle Size Drug Carriers Myocardium Heart Rat heart Silicon Dioxide Biocompatible material Rats medicine.anatomical_structure chemistry Biophysics Nanoparticles Particle size Drug carrier Biomedical engineering |
| Zdroj: | Biomedical Materials. 2:220-223 |
| ISSN: | 1748-605X 1748-6041 |
| DOI: | 10.1088/1748-6041/2/4/003 |
| Popis: | Silica powders consisting of small spherical particles (50-200 nm) have been obtained by the sol-gel method. A suspension of such particles in the Krebs-Hanseleit solution has been introduced into the coronary circulation of a beating perfused rat heart. The influence of the suspension on the heart muscle and the coronary vessels in the rat body has been histopathologically examined. The particles have not left the lumen of the vessels and have not caused any side effects. These observations suggest the possibility of using such silica particles as a carrier for selected drugs. |
| Databáze: | OpenAIRE |
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