Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy
| Autor: | Jun Nomura, Yoshiteru Sasaki, Morihisa Hirota, Kazuhiro Murakami, Junichi Kameoka, Tomonori Satoh, Yuki Yoshino, Katsuya Endo, Atsuko Takasu, Shiho Kondo, Keigo Murakami, Daisuke Fukushi, Takayoshi Meguro, Takehito Ito, Kennichi Satoh, Takayuki Kogure |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
History
Pathology medicine.medical_specialty Polymers and Plastics Case Report RC799-869 Industrial and Manufacturing Engineering Immunoglobulin Light-chain Amyloidosis 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine AL amyloidosis Enteropathy Business and International Management Bone pain Multiple myeloma business.industry Amyloidosis Protein losing enteropathy Plasma cell neoplasm Diseases of the digestive system. Gastroenterology medicine.disease 030220 oncology & carcinogenesis medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Case Reports in Gastrointestinal Medicine, Vol 2021 (2021) Case Reports in Gastrointestinal Medicine |
| ISSN: | 2090-6536 2090-6528 |
| Popis: | Multiple myeloma is a type of plasma cell neoplasm that produces monoclonal immunoglobulin. Multiple myeloma is known to cause immunoglobulin light-chain (AL) amyloidosis, which frequently involves the kidney and heart. Bone pain or fractures caused by osteolytic lesions and physical disorders related to renal or cardiac AL amyloidosis are major initial symptoms in multiple myeloma. Multiple myeloma diagnosed from the gastrointestinal symptoms is rare. We report a case of an 80-year-old man with multiple myeloma accompanied by gastrointestinal AL amyloidosis and secondary protein-losing enteropathy. The diagnostic process was suggestive, in that diarrhea and refractory leg edema related to protein-losing enteropathy were the primary symptoms and the trigger for making a sequential diagnosis of gastrointestinal AL amyloidosis and underlying multiple myeloma. This case is highly suggestive, in that multiple myeloma with gastrointestinal AL amyloidosis should be considered one of the background diseases of protein-losing enteropathy. |
| Databáze: | OpenAIRE |
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