The evolution of histological changes suggestive of antibody-mediated injury, in the presence and absence of donor-specific anti-HLA antibodies
| Autor: | Aleksandar Senev, Geert Verbeke, Marie-Paule Emonds, Evelyne Lerut, Ben Sprangers, Maarten Naesens, Dirk Kuypers, Maarten Coemans, Elisabet Van Loon |
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| Rok vydání: | 2021 |
| Předmět: |
Graft Rejection
medicine.medical_specialty Graft failure Gastroenterology Kidney transplantation Cohort Studies HLA Antigens Isoantibodies Internal medicine Medicine Humans Hla antibodies Subclinical infection Transplantation biology business.industry Graft Survival Histology Transplant glomerulopathy medicine.disease Kidney Transplantation Tissue Donors joint modeling HLA-DSA biology.protein aABMRh Antibody business Cohort study |
| Zdroj: | Transplant international : official journal of the European Society for Organ TransplantationREFERENCES. 34(10) |
| ISSN: | 1432-2277 |
| Popis: | The interplay between donor-specific anti-HLA antibodies (HLA-DSA), histology of active antibody-mediated rejection (aABMRh ), transplant glomerulopathy (cg), and graft failure in kidney transplantation remains insufficiently understood. We performed a single-center cohort study (n = 1000) including 2761 protocol and 833 indication biopsies. Patients with pretransplant HLA-DSA were more prone to develop aABMRh (OR 22.7, 95% CI, 11.8-43.7, P |
| Databáze: | OpenAIRE |
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