Rs4948496 withinARID5Bgene is associated with clinical features of systemic lupus erythematosus in the Chinese Han population
| Autor: | Zaixing Wang, Liangdan Sun, Jianping Wu, Hui Li, Juan Du, Xiaodong Zheng, Yujun Sheng, Xianyong Yin, Sen Yang, Wenjun Wang, Ming Zeng, Long Jiang, Huayang Tang, Xing Fan, Yong Cui, Jinping Gao, Zhengwei Zhu, Xuejun Zhang, Li Meng, Weiran Li, Shengxiu Liu, Yang Li |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male China medicine.medical_specialty Adolescent Genotype Anti-nuclear antibody Single-nucleotide polymorphism Dermatology Disease Polymorphism Single Nucleotide Gastroenterology Young Adult Asian People Internal medicine medicine Humans Lupus Erythematosus Systemic SNP Child Aged Aged 80 and over business.industry Infant General Medicine Odds ratio Middle Aged Confidence interval DNA-Binding Proteins Phenotype Antibodies Antinuclear Case-Control Studies Child Preschool Cohort Immunology Female business Transcription Factors |
| Zdroj: | The Journal of Dermatology. 42:608-612 |
| ISSN: | 0385-2407 |
| Popis: | In our previous meta-analysis of genome-wide association study, we identified the single nucleotide polymorphism (SNP) rs4948496 (P = 5.1 × 10(-11) , odds ratio [OR] = 0.85) within the ARID5B gene associated with systemic lupus erythematosus (SLE) in a Chinese population. To investigate its association with disease subphenotypes, we further analyzed the genotype data of rs4948496 in 4348 cases and 6679 controls from our previous meta-analysis and an independent replication cohort in this study. The SNP rs4948496 was significantly associated with SLE (P = 1.61 × 10(-5) , OR = 0.88, 95% confidence interval [CI] = 0.83-0.93) in our group. In case-only study, the genotype of rs4948496 was associated with antinuclear antibodies (P = 0.03, OR = 0.81, 95% CI = 0.68-0.98) and anti-RNP (P = 0.03, OR = 0.86, 95% CI = 0.76-0.99). This study showed that rs4948496 in ARID5B is associated with several subphenotypes of SLE and this gene may cause the complicacy of clinical features. |
| Databáze: | OpenAIRE |
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