24-Year Results of Nonfenestrated Extracardiac Fontan Including Fontan Conversions

Autor: Carl L. Backer, Paul J. Devlin, Sabrina Tsao, Elizabeth H. Stephens, Michael C. Mongé, Abhinav A. Talwar, Osama Eltayeb
Rok vydání: 2021
Předmět:
Adult
Heart Defects
Congenital
Male
Pulmonary and Respiratory Medicine
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_specialty
Adolescent
Cardiopulmonary bypass time
030204 cardiovascular system & hematology
Fontan Procedure
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Humans
Medicine
Statistical analysis
cardiovascular diseases
Risk factor
Child
Retrospective Studies
Ventricular function
business.industry
Operative mortality
Retrospective cohort study
Perioperative
Transplantation
Treatment Outcome
surgical procedures
operative
030228 respiratory system
Child
Preschool
cardiovascular system
Cardiology
Female
Surgery
Cardiology and Cardiovascular Medicine
business
human activities
Follow-Up Studies
Forecasting
Zdroj: The Annals of Thoracic Surgery. 112:619-625
ISSN: 0003-4975
Popis: Background There is active debate regarding the optimal method of Fontan palliation. In light of this, we reviewed our experience with the nonfenestrated extracardiac Fontan including Fontan conversion. Methods We performed a retrospective review of all nonfenestrated extracardiac Fontan and Fontan conversion operations at our institution from December 1, 1994 to December 31, 2018. Standard demographic data were collected, including underlying anatomy, preoperative ventricular and valvular function, operative details, perioperative data, and clinical outcomes. Statistical analysis included comparison between initial extracardiac Fontan patients and Fontan conversions, as well as analysis of risk factors for adverse outcomes. Results There were 341 patients with an overall operative mortality of 4 patients (1.2%). Of these, 193 were extracardiac nonfenestrated Fontan completion operations (57%) and 148 were Fontan conversions (43%). Length of stay was 11 days (SD, 6 days) with ventilator duration of 28 hours (SD, 26 hours). Six of the completion Fontan patients (3%) required Fontan takedown at a median time of 2.5 days. Upon multivariable analysis, risk factors associated with adverse events (mortality, Fontan takedown, and/or transplant) included increased cardiopulmonary bypass time, preoperative decreased dominant ventricular function, and length of stay. Kaplan-Meier curves demonstrated that mild or greater preoperative ventricular dysfunction decreased survival as well as freedom from adverse events for both initial extracardiac Fontan and Fontan conversion patients. Conclusions Over the past 24 years, our strategy of nonfenestrated extracardiac Fontan has achieved low operative mortality for both initial Fontan and Fontan conversion. There is a steady attrition of Fontan patients to cardiac transplantation; the key risk factor is preoperative ventricular dysfunction.
Databáze: OpenAIRE
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