A Feed-Forward Circuit Linking Wingless, Fat-Dachsous Signaling, and the Warts-Hippo Pathway to Drosophila Wing Growth
| Autor: | Gary Struhl, Myriam Zecca |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cell signaling
Life Cycles Signal transduction Epithelium Signal Initiation Larvae Animal Cells Gene expression Morphogenesis Medicine and Health Sciences Drosophila Proteins Homeostasis Wings Animal Biology (General) General Neuroscience Drosophila Melanogaster Mechanisms of Signal Transduction Wnt signaling pathway Gene Expression Regulation Developmental Nuclear Proteins Signaling cascades Eukaryota Animal Models Cell biology Insects Experimental Organism Systems Bone Morphogenetic Proteins DPP signaling cascade Drosophila Gene Cloning Cellular Types Anatomy General Agricultural and Biological Sciences Morphogen Research Article animal structures Arthropoda QH301-705.5 Protocadherin Wnt1 Protein Biology Research and Analysis Methods General Biochemistry Genetics and Molecular Biology Model Organisms Animals Molecular Biology Techniques Molecular Biology Wing General Immunology and Microbiology Decapentaplegic Mechanism (biology) Parietal Cells Organisms Biology and Life Sciences Epithelial Cells Molecular Development Invertebrates Wnt Proteins Morphogens Biological Tissue Animal Studies Zoology Entomology Function (biology) Cloning Developmental Biology |
| Zdroj: | PLoS Biology, Vol 19, Iss 3, p e3001111 (2021) PLoS Biology |
| ISSN: | 1545-7885 1544-9173 |
| Popis: | Development of the Drosophila wing—a paradigm of organ development—is governed by 2 morphogens, Decapentaplegic (Dpp, a BMP) and Wingless (Wg, a Wnt). Both proteins are produced by defined subpopulations of cells and spread outwards, forming gradients that control gene expression and cell pattern as a function of concentration. They also control growth, but how is unknown. Most studies have focused on Dpp and yielded disparate models in which cells throughout the wing grow at similar rates in response to the grade or temporal change in Dpp concentration or to the different amounts of Dpp “equalized” by molecular or mechanical feedbacks. In contrast, a model for Wg posits that growth is governed by a progressive expansion in morphogen range, via a mechanism in which a minimum threshold of Wg sustains the growth of cells within the wing and recruits surrounding “pre-wing” cells to grow and enter the wing. This mechanism depends on the capacity of Wg to fuel the autoregulation of vestigial (vg)—the selector gene that specifies the wing state—both to sustain vg expression in wing cells and by a feed-forward (FF) circuit of Fat (Ft)/Dachsous (Ds) protocadherin signaling to induce vg expression in neighboring pre-wing cells. Here, we have subjected Dpp to the same experimental tests used to elucidate the Wg model and find that it behaves indistinguishably. Hence, we posit that both morphogens act together, via a common mechanism, to control wing growth as a function of morphogen range. Drosophila wing growth depends on the progressive outward spread of the morphogens Decapentaplegic (a member of the BMP family) and Wingless (a member of the Wnt family) via their capacity to sustain the growth of wing cells and to induce neighboring cells to grow and enter the wing. |
| Databáze: | OpenAIRE |
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