Signs of beta-cell autoimmunity and HLA-defined diabetes susceptibility in the Finnish population: the sib cohort from the Type 1 Diabetes Prediction and Prevention Study
| Autor: | Olli Simell, Jorma Ilonen, Petri Kulmala, P. Keskinen, Sari Korhonen, Tuula Simell, K. Savola, Mikael Knip, M. Kukko, A. Kupila, T. Kimpimäki |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Genotype Endocrinology Diabetes and Metabolism Population Autoimmunity Human leukocyte antigen Biology Antibodies Cohort Studies Islets of Langerhans HLA Antigens Diabetes mellitus Internal Medicine medicine Humans Insulin Genetic Predisposition to Disease Allele education Finland Autoantibodies Type 1 diabetes education.field_of_study HLA-DQB1 Glutamate Decarboxylase Autoantibody Prognosis medicine.disease Isoenzymes Diabetes Mellitus Type 1 Immunology Female |
| Zdroj: | Diabetologia. 46:65-70 |
| ISSN: | 1432-0428 0012-186X |
| Popis: | Aims/hypothesis. To assess the role of HLA-defined genetic diabetes susceptibility in the appearance of signs of beta-cell autoimmunity in a series of children derived from the general population. Methods. Tests for five HLA DQB1 alleles and four diabetes-associated autoantibodies were carried out on 1,584 older sibs of infants with an increased HLA-defined genetic risk of Type 1 diabetes. The DQB1 genotypes were classified into those conferring high (*02/0302), moderate (*0302/x; where x indicates *0302 or a non-defined allele), low (*0301/0302, *02/0301, *02/x, *0302/0602, *0302/0603; where x indicates *02 or a non-defined allele) or decreased risk (other genotypes). Results. Both islet cell antibodies (ICA) and GAD65 antibodies (GADA) were more frequent among the sibs with the high-risk genotype than among those with a low or decreased risk. Insulin autoantibodies and IA-2 antibodies (IA-2A) were more prevalent in the high-risk than low-risk sibs. Sibs with moderate-risk genotypes tested positive for ICA, GADA and IA-2A more often than sibs with genotypes conferring decreased risk. Autoantibody titres were also dependent on the genetic risk with high risk sibs having the highest values. Sibs carrying high-risk or moderate-risk genotypes tested positive for multiple antibodies (≥2) more often than did the sibs with low or decreased genetic risk. Conclusions/interpretation. The data show that HLA-defined susceptibility to Type 1 diabetes has an effect on both the quality and quantity of humoral beta-cell autoimmunity in unaffected children derived from the general population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink