Photodynamic therapy guidelines for the management of oral leucoplakia
| Autor: | Junxin Cheng, Fan Tang, Hongxia Dan, Hang Zhao, Xiaoying Li, Jiongke Wang, Xin Zeng, Qianming Chen |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Mucositis medicine.medical_specialty Oral leucoplakia medicine.medical_treatment MEDLINE Photodynamic therapy Review Article Light delivery law.invention 03 medical and health sciences Therapeutic approach 0302 clinical medicine Randomized controlled trial law Interim medicine Humans Intensive care medicine General Dentistry Photosensitizing Agents business.industry 030206 dentistry Aminolevulinic Acid Disfigurement lcsh:RK1-715 030104 developmental biology Combination drug therapy Photochemotherapy lcsh:Dentistry Practice Guidelines as Topic Leukoplakia Oral business |
| Zdroj: | International Journal of Oral Science International Journal of Oral Science, Vol 11, Iss 2, Pp 1-5 (2019) |
| ISSN: | 2049-3169 |
| Popis: | With recent developments in photosensitizers and light delivery systems, topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) has become the fourth alternative therapeutic approach in the management of oral leucoplakia (OLK) due to its minimally invasive nature, efficacy, and low risk of systemic side effects and disfigurement. This report presents step-by-step guidelines for applying topical ALA-PDT in the management of OLK based on both the clinical experience of the authors and a systematic review of the current literature. Studies using protocols with standardized parameters and randomized clinical trials at multiple centres with adequate sample sizes and both interim and long-term follow-ups are needed before universally applicable guidelines can be produced in this field. Oral lesions: a lighter touch for treatment Light-mediated therapy is a promising approach for treatment of oral leukoplakia (OLK), white patches inside the mouth that cannot be wiped away and that can become cancerous. Surgical removal carries a risk of damaging delicate facial structures, or causing potentially disfiguring scarring. Hang Zhao and Xin Zeng at the West China Hospital of Stomatology and coworkers have reviewed use of photodynamic therapy (PDT), a minimally invasive alternative to treat OLK. For treatment, the lesion is coated with a photosensitizer solution, then illuminated with a laser (or LED), triggering release of reactive oxygen species, which kill nearby cells. The treatment can be focused very precisely on a specific tissue, without damaging other cells. The researchers recommend further research to determine long-term effectiveness against OLK, and to develop standardized protocols for wider application of this promising method. |
| Databáze: | OpenAIRE |
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