Reappearance of Symptoms after GPi‐DBS Discontinuation in Cervical Dystonia
| Autor: | Jaana Korpela, Eero Pekkonen, Martin M. Reich, Juho Joutsa, Emma A. Honkanen, Valtteri Kaasinen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Deep brain stimulation medicine.medical_treatment dystonia deep brain stimulation internal globus pallidus neuromodulation brain stimulation Spasmodic Torticollis Stimulation 030105 genetics & heredity 03 medical and health sciences 0302 clinical medicine medicine Cervical dystonia Research Articles Dystonia business.industry Therapeutic effect medicine.disease 3. Good health Discontinuation nervous system diseases Neurology nervous system Anesthesia Brain stimulation Neurology (clinical) business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Movement Disorders Clinical Practice |
| ISSN: | 2330-1619 |
| Popis: | Background Deep brain stimulation of the globus pallidus interna (GPi‐DBS) is a highly efficacious treatment for cervical dystonia. Typically, the treatment response is delayed, appearing and increasing even months after implantation. However, it is not known how fast the symptoms reappear and whether there is a long‐term therapeutic effect after the stimulation is discontinued. Objectives To study symptom reappearance after switching GPi‐DBS off in cervical dystonia. Methods Twelve patients with bilateral GPi‐DBS were included in the study. The Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) was evaluated during the study with DBS stimulation on, after switching the stimulation off and 2 days after the stimulation was switched off. Presurgical symptom severity and best postsurgical response were extracted from the hospital records. Results At the time of the investigation, GPi‐DBS was associated with 67 (SD 39)% symptom improvement of presurgical symptoms severity (P = 0.001). Symptom improvement decreased to 27 (53)% (P = 0.046) (n = 12) acutely after switching the stimulation off and was further reduced to 4 (56)% 2 days after discontinuation (P = 0.01) (n = 11), reaching the presurgical level (P = 0.42). In descriptive analyses, older age was associated with faster worsening of symptoms (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|