Tissue Regeneration: The Dark Side of Opioids

Autor: Anne Lorsignol, Cécile Dromard Berthézène, Béatrice Cousin, Louis Casteilla, Géraldine Jourdan, Luc Pénicaud, Lise Rabiller
Přispěvatelé: Geroscience and rejuvenation research center (RESTORE), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), McGill University = Université McGill [Montréal, Canada], Cousin, Béatrice
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Standard of care
QH301-705.5
Analgesic
Pain
Context (language use)
Review
Bioinformatics
opioid receptors
Catalysis
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
Managing pain
Medicine
Animals
Humans
Pain Management
tissue repair
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
QD1-999
Spectroscopy
Wound Healing
Nerve activity
business.industry
Regeneration (biology)
Organic Chemistry
opioids
General Medicine
Tissue repair
Regenerative process
3. Good health
Computer Science Applications
Analgesics
Opioid
Chemistry
030104 developmental biology
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
regeneration
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
business
030217 neurology & neurosurgery
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (14), pp.7336. ⟨10.3390/ijms22147336⟩
International Journal of Molecular Sciences, Vol 22, Iss 7336, p 7336 (2021)
International Journal of Molecular Sciences, 2021, 22 (14), pp.7336. ⟨10.3390/ijms22147336⟩
ISSN: 1661-6596
1422-0067
DOI: 10.3390/ijms22147336⟩
Popis: International audience; Opioids are regarded as among the most effective analgesic drugs and their use for the management of pain is considered standard of care. Despite their systematic administration in the peri-operative period, their impact on tissue repair has been studied mainly in the context of scar healing and is only beginning to be documented in the context of true tissue regeneration. Indeed, in mammals, growing evidence shows that opioids direct tissue repair towards scar healing, with a loss of tissue function, instead of the regenerative process that allows for recovery of both the morphology and function of tissue. Here, we review recent studies that highlight how opioids may prevent a regenerative process by silencing nociceptive nerve activity and a powerful anti-inflammatory effect. These data open up new perspectives for inducing tissue regeneration and argue for opioid-restricted strategies for managing pain associated with tissue injury.
Databáze: OpenAIRE
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