Combined Large Cell Neuroendocrine Carcinoma and Papillary Serous Carcinoma of the Endometrium With Pagetoid Spread

Autor:	Lorena, Posligua, Anais, Malpica, Jinsong, Liu, Jubilee, Brown, Michael T, Deavers
Rok vydání:	2008
Předmět:	Medical Laboratory Technology Humans Cell Differentiation Female General Medicine Middle Aged Combined Modality Therapy Carcinoma Papillary female genital diseases and pregnancy complications Carcinoma Neuroendocrine Endometrial Neoplasms Pathology and Forensic Medicine
Zdroj:	Archives of Pathology & Laboratory Medicine. 132:1821-1824
ISSN:	1543-2165 0003-9985
DOI:	10.5858/132.11.1821
Popis:	Neuroendocrine carcinomas of the endometrium are rare tumors that can be pure, combined with endometrioid adenocarcinoma, or a component of malignant mixed müllerian tumor. Recently, a case of combined small cell carcinoma and papillary serous carcinoma of the endometrium was described for the first time. We report the first case, to our knowledge, of combined large cell neuroendocrine carcinoma and papillary serous carcinoma of the endometrium, with an unusual pagetoid spread of the neuroendocrine component into normal endometrial and endocervical glands. The endometrial carcinoma had a small serous component, but most of the tumor was characterized by solid sheets of medium to large cells with abundant mitotic figures, numerous apoptotic bodies, and foci of necrosis. This component was diffusely positive for neuroendocrine markers. Following surgery, the patient was treated with radiation therapy and chemotherapy. She was without evidence of progression at 5 months of follow-up.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7a6160019666dbdbff209f8df7c044 https://doi.org/10.5858/132.11.1821 Zobrazit plný text záznamu Plný text ve formátu PDF