Serum inhibin B and anti-Müllerian hormone are not superior to follicle-stimulating hormone as predictors of the presence of sperm in testicular fine-needle aspiration in men with azoospermia
| Autor: | Christos Tsametis, Dimitrios G. Goulis, Basil C. Tarlatzis, Paris Polychronou, Persefoni-Dimitra Kantartzi, Paschalia K. Iliadou, Ioannis Papadimas, Ioannis Bontis |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Anti-Mullerian Hormone Male endocrine system Sperm Retrieval endocrine system diseases Biopsy Fine-Needle Varicocele Testicle Male infertility Andrology Follicle-stimulating hormone Cryptorchidism medicine Humans Inhibins reproductive and urinary physiology Azoospermia biology urogenital system business.industry Obstetrics and Gynecology Anti-Müllerian hormone Prognosis medicine.disease Spermatozoa Sperm medicine.anatomical_structure ROC Curve Reproductive Medicine biology.protein Follicle Stimulating Hormone business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Fertility and Sterility. 91:1279-1284 |
| ISSN: | 0015-0282 |
| Popis: | Objective To compare FSH, inhibin B (INHB), and anti-Mullerian hormone (AMH) as predictors of the recovery of sperm in testicular fine-needle aspiration biopsy (FNA) performed in men with azoospermia. Design Cross-sectional, clinical study. Setting Academic Unit of Reproductive Endocrinology. Patient(s) Fifty-one men with azoospermia and 31 controls. Intervention(s) Testicular FNA. Main Outcome Measure(s) Serum FSH, INHB, and AMH levels. Result(s) Clinical diagnoses in men with azoospermia were idiopathic nonobstructive azoospermia (n = 34, 67%), cryptorchidism (n = 4, 8%), varicocele (n = 3, 6%), and other diagnoses (n = 10, 16%). In pairwise comparison of receiver operating characteristic curves, none of FSH (area under curve 0.716), INHB (0.610), AMH (0.565), or volume of the larger testis (0.693) was proved to be superior to the others as predictor of sperm retrieval during an FNA procedure. Similarly, in a logistic regression analysis, none of FSH, AMH, INHB, or volume of the larger testis could predict presence of sperm in FNA. Conclusion(s) Serum INHB and AMH, as well as their combination, are not superior to FSH as predictors of the presence of sperm in testicular FNA in men with azoospermia and should not be used for this purpose. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|