Age may influence the impact of TRAbs on thyroid function and relapse-risk in patients with Graves' disease
| Autor: | Caroline Addison, Kilimangalam Narayanan, Salman Razvi, Jolanta U. Weaver, Vasileios Tsatlidis, Arjola Bano, Earn H Gan |
|---|---|
| Přispěvatelé: | Epidemiology, Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Oncology Endocrinology Diabetes and Metabolism Graves' disease Clinical Biochemistry Thyroid Gland Thyroid Function Tests Biochemistry 0302 clinical medicine Endocrinology Recurrence Prospective Studies Prospective cohort study 610 Medicine & health biology medicine.diagnostic_test Hazard ratio Age Factors Receptors Thyrotropin Middle Aged Prognosis Graves Disease 030220 oncology & carcinogenesis Female Thyroid function 360 Social problems & social services Immunoglobulins Thyroid-Stimulating Adult Thyroid Hormones medicine.medical_specialty 030209 endocrinology & metabolism Context (language use) Trab Thyroid function tests 03 medical and health sciences Thyroid peroxidase Internal medicine medicine Humans business.industry Biochemistry (medical) medicine.disease Cross-Sectional Studies biology.protein business Biomarkers Follow-Up Studies |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 104(5), 1378-1385. Endocrine Society Bano, Arjola; Gan, Earn; Addison, Caroline; Narayanan, Kilimangalam; Weaver, Jolanta U; Tsatlidis, Vasileios; Razvi, Salman (2019). Age may influence the impact of TRAbs on thyroid function and relapse-risk in patients with Graves' disease. Journal of clinical endocrinology and metabolism, 104(5), pp. 1378-1385. Endocrine Society 10.1210/jc.2018-01738 |
| ISSN: | 0021-972X |
| DOI: | 10.7892/boris.122508 |
| Popis: | Context Thyrotropin receptor antibodies (TRAbs) play a crucial role in the pathogenesis of Graves' disease (GD). However, factors that influence the association of TRAbs with thyroid hormones and relapse risk in GD remain unclear. Objective We investigated: (i) the associations of TRAbs at diagnosis with thyroid hormones and relapse risk; (ii) potential factors that can influence these associations in GD. Design and Setting A prospective study in GD patients from a single endocrine centre in the north-east of England, seen between January 2008 and March 2018. Patients and Main outcome measures Consecutive GD patients (n=384) who had measurements of TRAbs, free thyroxine and free triiodothyronine at diagnosis. The association of TRAbs with thyroid hormones and relapse risk was assessed through linear regression and Cox proportional hazard models, adjusted for potential confounders. Results TRAbs were non-linearly associated with thyroid hormones, following a curve with an initial positive slope and a subsequent flattening (p-values |
| Databáze: | OpenAIRE |
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