Artificial cilia for active micro-fluidic mixing

Autor: Titie Mol, Dick J. Broer, Femke Bos, Jaap M.J. den Toonder, Wim Talen, Murray F. Gillies, Judith de Goede, Laura Filippini, Patrick D. Anderson, Hans T. A. Wilderbeek, VV Vinayak Khatavkar, Mireille Reijme
Přispěvatelé: Processing and Performance, Microsystems, Group Den Toonder, Institute for Complex Molecular Systems
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: Lab on a Chip, 8(4), 533-541. Royal Society of Chemistry
ISSN: 1473-0197
Popis: In lab-on-chip devices, on which complete (bio-)chemical analysis laboratories are miniaturized and integrated, it is essential to manipulate fluids in sub-millimetre channels and sub-microlitre chambers. A special challenge in these small micro-fluidic systems is to create good mixing flows, since it is almost impossible to generate turbulence. We propose an active micro-fluidic mixing concept inspired by nature, namely by micro-organisms that swim through a liquid by oscillating microscopic hairs, cilia, that cover their surface. We have fabricated artificial cilia consisting of electro-statically actuated polymer structures, and have integrated these in a micro-fluidic channel. Flow visualization experiments show that the cilia can generate substantial fluid velocities, up to 0.6 mm s(-1). In addition, very efficient mixing is obtained using specially designed geometrical cilia configurations in a micro-channel. Since the artificial cilia can be actively controlled using electrical signals, they have exciting applications in micro-fluidic devices.
Databáze: OpenAIRE